The ESRB ratings board has rated Destroy All Humans! for the PlayStation 4 console with a T for Teen rating for: "Language, Sexual Themes, Violence." It is the same rating as the original release on PlayStation 2, Xbox, and Xbox 360 by THQ Inc. It was also rated by the PEGI rating board in Europe for PlayStation 4 as well.

This PlayStation 4 version is by THQ Nordic GmbH which was previously Nordic Games GmbH but re-branded after obtaining the THQ brand.

The original Destroy All Humans! released in June of 2005. This rating is most likely for a PS2 to PS4 release, though there is still no official word from THQ Nordic about the release.