Duke Nukem 3D has been ported to nearly every console that has been in existence, including the Sega Genesis. However, that version only ever released in Brazil. Now, thanks to Piko Interactive, that edition is releasing for collectors and retro game enthusiasts worldwide. Starting the first week of November, the website will begin shipping cartridges for the Genesis, or the Mega Drive as it was known outside of North America.

Current pre-orders list a cartridge only option for $39.99, or an in-box edition for $54.99 which includes, "Game Cartridge, HIGH QUALITY Sega Genesis Case, and Color Instruction Manual." The Sega Genesis version only included  Lunar Apocalypse, the second episode of the original's three episode structure. Due to the difference in hardware the graphics were also modified to work with the Genesis.