This looks like it’s going to be a good year for Spider-Man, as Joystiq reports that Activision and Beenox will be releasing a new Spider-Man game later this year. No further details have been revealed at this point, but as Comics Alliance points out there is a new animated series based on the Ultimate Spider-Man comics coming later this year. Ultimate Spider-Man appeared in Shattered Dimensions (developed by Beenox) and Activision made a full Ultimate Spider-Man game in 2005, so a sequel to either of those wouldn’t be out of the question.
Personally I’m thinking a new Shattered Dimensions game. There are a few other dimensions that could still be explored. The biggest one that hasn’t been represented yet is of course the Marvel Zombies universe, which would just be awesome.