Tyrone Rodriguez, producer and developer for The Binding of Isaac: Rebirth, recently tweeted a picture of Apple responding to his apparent submission of The Binding of Isaac: Rebirth for iOS devices.The response stated that there was "1 unresolved iOS issue" which was:

15.2 Details Your app contains content or features that depict violence towards, or abuse of, children, which is not allowed on the App.

This is the first confirmation that The Binding of Isaac: Rebirth is coming to iOS. The possibility was only mentioned on Edmund McMillen's Tumblr blog three years ago with the statement, "we are also looking into an iOS version if its not garbage."